Unscheduled epigenetic modifications cause genome instability and sterility through aberrant R-loops following starvation

During starvation, organisms modify both gene expression and metabolism to adjust to the energy stress. We previously reported that Caenorhabditis elegans lacing AMP-activated protein kinase (AMPK) exhibit transgenerational reproductive defects associated with abnormally elevated trimethylated histo...

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Detalles Bibliográficos
Autores principales: Sun, Bing, Sherrin, McLean, Roy, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841415/
https://www.ncbi.nlm.nih.gov/pubmed/36504323
http://dx.doi.org/10.1093/nar/gkac1155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841415/
https://www.ncbi.nlm.nih.gov/pubmed/36504323
http://dx.doi.org/10.1093/nar/gkac1155

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