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Unscheduled epigenetic modifications cause genome instability and sterility through aberrant R-loops following starvation
During starvation, organisms modify both gene expression and metabolism to adjust to the energy stress. We previously reported that Caenorhabditis elegans lacing AMP-activated protein kinase (AMPK) exhibit transgenerational reproductive defects associated with abnormally elevated trimethylated histo...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841415/ https://www.ncbi.nlm.nih.gov/pubmed/36504323 http://dx.doi.org/10.1093/nar/gkac1155 |