Mycobacterial helicase Lhr abets resistance to DNA crosslinking agents mitomycin C and cisplatin

Mycobacterium smegmatis Lhr exemplifies a novel clade of helicases composed of an N-terminal ATPase/helicase domain (Lhr-Core) and a large C-terminal domain (Lhr-CTD) that nucleates a unique homo-tetrameric quaternary structure. Expression of Lhr, and its operonic neighbor Nei2, is induced in mycoba...

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Detalles Bibliográficos
Autores principales: Warren, Garrett M, Ejaz, Anam, Fay, Allison, Glickman, Michael S, Shuman, Stewart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841417/
https://www.ncbi.nlm.nih.gov/pubmed/36610794
http://dx.doi.org/10.1093/nar/gkac1222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841417/
https://www.ncbi.nlm.nih.gov/pubmed/36610794
http://dx.doi.org/10.1093/nar/gkac1222

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