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Monitoring translation in all reading frames downstream of weak stop codons provides mechanistic insights into the impact of nucleotide and cellular contexts

A stop codon entering the ribosome A-site is normally decoded by release factors that induce release of the polypeptide. Certain factors influence the efficiency of the termination which is in competition with elongation in either the same (readthrough) or an alternative (frameshifting) reading fram...

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Detalles Bibliográficos
Autores principales: Loughran, Gary, Li, Xiang, O’Loughlin, Sinead, Atkins, John F, Baranov, Pavel V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841425/
https://www.ncbi.nlm.nih.gov/pubmed/36533511
http://dx.doi.org/10.1093/nar/gkac1180