Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate no-go decay

Ribosome collisions are recognized by E3 ubiquitin ligase Hel2/ZNF598, leading to RQC (ribosome-associated quality control) and to endonucleolytic cleavage and degradation of the mRNA termed NGD (no-go decay). NGD in yeast requires the Cue2 endonuclease and occurs in two modes, either coupled to RQC...

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Detalles Bibliográficos
Autores principales: Tomomatsu, Shota, Watanabe, Atsuya, Tesina, Petr, Hashimoto, Satoshi, Ikeuchi, Ken, Li, Sihan, Matsuo, Yoshitaka, Beckmann, Roland, Inada, Toshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841427/
https://www.ncbi.nlm.nih.gov/pubmed/36583309
http://dx.doi.org/10.1093/nar/gkac1172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841427/
https://www.ncbi.nlm.nih.gov/pubmed/36583309
http://dx.doi.org/10.1093/nar/gkac1172

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