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Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate no-go decay
Ribosome collisions are recognized by E3 ubiquitin ligase Hel2/ZNF598, leading to RQC (ribosome-associated quality control) and to endonucleolytic cleavage and degradation of the mRNA termed NGD (no-go decay). NGD in yeast requires the Cue2 endonuclease and occurs in two modes, either coupled to RQC...
Autores principales: | Tomomatsu, Shota, Watanabe, Atsuya, Tesina, Petr, Hashimoto, Satoshi, Ikeuchi, Ken, Li, Sihan, Matsuo, Yoshitaka, Beckmann, Roland, Inada, Toshifumi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841427/ https://www.ncbi.nlm.nih.gov/pubmed/36583309 http://dx.doi.org/10.1093/nar/gkac1172 |
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