Insights into the molecular mechanism of translation inhibition by the ribosome-targeting antibiotic thermorubin

Thermorubin (THR) is an aromatic anthracenopyranone antibiotic active against both Gram-positive and Gram-negative bacteria. It is known to bind to the 70S ribosome at the intersubunit bridge B2a and was thought to inhibit factor-dependent initiation of translation and obstruct the accommodation of...

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Detalles Bibliográficos
Autores principales: Paranjpe, Madhura N, Marina, Valeria I, Grachev, Aleksandr A, Maviza, Tinashe P, Tolicheva, Olga A, Paleskava, Alena, Osterman, Ilya A, Sergiev, Petr V, Konevega, Andrey L, Polikanov, Yury S, Gagnon, Matthieu G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841432/
https://www.ncbi.nlm.nih.gov/pubmed/36546783
http://dx.doi.org/10.1093/nar/gkac1189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841432/
https://www.ncbi.nlm.nih.gov/pubmed/36546783
http://dx.doi.org/10.1093/nar/gkac1189

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