Cargando…

Insights into the molecular mechanism of translation inhibition by the ribosome-targeting antibiotic thermorubin

Thermorubin (THR) is an aromatic anthracenopyranone antibiotic active against both Gram-positive and Gram-negative bacteria. It is known to bind to the 70S ribosome at the intersubunit bridge B2a and was thought to inhibit factor-dependent initiation of translation and obstruct the accommodation of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paranjpe, Madhura N, Marina, Valeria I, Grachev, Aleksandr A, Maviza, Tinashe P, Tolicheva, Olga A, Paleskava, Alena, Osterman, Ilya A, Sergiev, Petr V, Konevega, Andrey L, Polikanov, Yury S, Gagnon, Matthieu G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841432/ https://www.ncbi.nlm.nih.gov/pubmed/36546783 http://dx.doi.org/10.1093/nar/gkac1189

Ejemplares similares

Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state
por: Osterman, Ilya A., et al.
Publicado: (2017)

Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. coli 70S ribosome
por: Pichkur, Evgeny B., et al.
Publicado: (2020)

Ribosomal protein S18 acetyltransferase RimI is responsible for the acetylation of elongation factor Tu
por: Pletnev, Philipp I., et al.
Publicado: (2022)

Binding and Action of Triphenylphosphonium Analog of Chloramphenicol upon the Bacterial Ribosome
por: Chen, Chih-Wei, et al.
Publicado: (2021)

Multifaceted Mechanism of Amicoumacin A Inhibition of Bacterial Translation
por: Maksimova, Elena M., et al.
Publicado: (2021)

RtcB2-PrfH Operon Protects E. coli ATCC25922 Strain from Colicin E3 Toxin
por: Maviza, Tinashe P., et al.
Publicado: (2022)

Klebsazolicin inhibits 70S ribosome by obstruction of the peptide exit tunnel
por: Metelev, Mikhail, et al.
Publicado: (2017)

Differential Contribution of Protein Factors and 70S Ribosome to Elongation
por: Paleskava, Alena, et al.
Publicado: (2021)

Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome
por: Melnikov, Sergey V., et al.
Publicado: (2016)

Antibiotic thermorubin tethers ribosomal subunits and impedes A-site interactions to perturb protein synthesis in bacteria
por: Parajuli, Narayan Prasad, et al.
Publicado: (2023)

Recurrent RNA motifs as probes for studying RNA-protein interactions in the ribosome
por: Gagnon, Matthieu G., et al.
Publicado: (2010)

How the initiating ribosome copes with ppGpp to translate mRNAs
por: Vinogradova, Daria S., et al.
Publicado: (2020)

Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site
por: Melnikov, Sergey V, et al.
Publicado: (2019)

The cyclic octapeptide antibiotic argyrin B inhibits translation by trapping EF-G on the ribosome during translocation
por: Wieland, Maximiliane, et al.
Publicado: (2022)

Structural basis for the inability of chloramphenicol to inhibit peptide bond formation in the presence of A-site glycine
por: Syroegin, Egor A, et al.
Publicado: (2022)

Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition
por: Gagnon, Matthieu G., et al.
Publicado: (2016)

The crystal structure of unmodified tRNA(Phe) from Escherichia coli
por: Byrne, Robert T., et al.
Publicado: (2010)

Ribosome-controlled transcription termination is essential for the production of antibiotic microcin C
por: Zukher, Inna, et al.
Publicado: (2014)

Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome
por: Prokhorova, Irina V., et al.
Publicado: (2016)

The C-terminal fragment of the ribosomal P protein complexed to trichosanthin reveals the interaction between the ribosome-inactivating protein and the ribosome
por: Too, Priscilla Hiu-Mei, et al.
Publicado: (2009)

The Mechanisms of Action of Ribosome-Targeting Peptide Antibiotics
por: Polikanov, Yury S., et al.
Publicado: (2018)

Epitranscriptomics of Mammalian Mitochondrial Ribosomal RNA
por: Laptev, Ivan, et al.
Publicado: (2020)

Comparison of mRNA features affecting translation initiation and reinitiation
por: Osterman, Ilya A., et al.
Publicado: (2013)

Techniques for Screening Translation Inhibitors
por: Osterman, Ilya A., et al.
Publicado: (2016)

Conjugates of Chloramphenicol Amine and Berberine as Antimicrobial Agents
por: Pavlova, Julia A., et al.
Publicado: (2022)

YoeB–ribosome structure: a canonical RNase that requires the ribosome for its specific activity
por: Feng, Shu, et al.
Publicado: (2013)

Role of Era in assembly and homeostasis of the ribosomal small subunit
por: Razi, Aida, et al.
Publicado: (2019)

Ribosomal RNA guanine-(N2)-methyltransferases and their targets
por: Sergiev, Petr V., et al.
Publicado: (2007)

The conserved GTPase HflX is a ribosome splitting factor that binds to the E-site of the bacterial ribosome
por: Coatham, Mackenzie L., et al.
Publicado: (2016)

Cryo-EM structure of the spinach chloroplast ribosome reveals the location of plastid-specific ribosomal proteins and extensions
por: Graf, Michael, et al.
Publicado: (2017)

Structural motifs of the bacterial ribosomal proteins S20, S18 and S16 that contact rRNA present in the eukaryotic ribosomal proteins S25, S26 and S27A, respectively
por: Malygin, Alexey A., et al.
Publicado: (2010)

A proton wire to couple aminoacyl-tRNA accommodation and peptide bond formation on the ribosome
por: Polikanov, Yury S., et al.
Publicado: (2014)

Unique localization of the plastid-specific ribosomal proteins in the chloroplast ribosome small subunit provides mechanistic insights into the chloroplastic translation
por: Ahmed, Tofayel, et al.
Publicado: (2017)

Structural basis of sequestration of the anti-Shine-Dalgarno sequence in the Bacteroidetes ribosome
por: Jha, Vikash, et al.
Publicado: (2020)

Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome
por: Pellegrino, Simone, et al.
Publicado: (2019)

Structural insights into the binding of bS1 to the ribosome
por: D’Urso, Gaetano, et al.
Publicado: (2023)

Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly
por: Polikanov, Yury S., et al.
Publicado: (2015)

Ribosomes in the balance: structural equilibrium ensures translational fidelity and proper gene expression
por: Musalgaonkar, Sharmishtha, et al.
Publicado: (2014)

Comprehensive Functional Analysis of Escherichia coli Ribosomal RNA Methyltransferases
por: Pletnev, Philipp, et al.
Publicado: (2020)

Binding of eIF3 in complex with eIF5 and eIF1 to the 40S ribosomal subunit is accompanied by dramatic structural changes
por: Zeman, Jakub, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3urds2k7gbp6358pm44j3or37q