Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development

NSP14 is a dual function enzyme containing an N-terminal exonuclease domain (ExoN) and C-terminal Guanine-N7-methyltransferase (N7-MTase) domain. Both activities are essential for the viral life cycle and may be targeted for anti-viral therapeutics. NSP14 forms a complex with NSP10, and this interac...

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Detalles Bibliográficos
Autores principales: Imprachim, Nergis, Yosaatmadja, Yuliana, Newman, Joseph A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841433/
https://www.ncbi.nlm.nih.gov/pubmed/36546776
http://dx.doi.org/10.1093/nar/gkac1207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841433/
https://www.ncbi.nlm.nih.gov/pubmed/36546776
http://dx.doi.org/10.1093/nar/gkac1207

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