Transpulmonary generation of cell‐free hemoglobin contributes to vascular dysfunction in pulmonary arterial hypertension via dysregulated clearance mechanisms

Circulating cell‐free hemoglobin (CFH) is elevated in pulmonary arterial hypertension (PAH) and associated with poor outcomes but the mechanisms are unknown. We hypothesized that CFH is generated from the pulmonary circulation and inadequately cleared in PAH. Transpulmonary CFH (difference between w...

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Detalles Bibliográficos
Autores principales: Meegan, Jamie E., Kerchberger, Vern Eric, Fortune, Niki L., McNeil, Joel Brennan, Bastarache, Julie A., Austin, Eric D., Ware, Lorraine B., Hemnes, Anna R., Brittain, Evan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841468/
https://www.ncbi.nlm.nih.gov/pubmed/36743426
http://dx.doi.org/10.1002/pul2.12185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841468/
https://www.ncbi.nlm.nih.gov/pubmed/36743426
http://dx.doi.org/10.1002/pul2.12185

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