Structure-Based Rational Design of Small α-Helical Peptides with Broad-Spectrum Activity against Multidrug-Resistant Pathogens

[Image: see text] A series of small (7–12 mer) amphipathic cationic peptides were designed and synthesized to create short helical peptides with broad-range bactericidal activity and selectivity toward the bacterial cells. The analysis identified a lead 12-mer peptide 8b with broad-spectrum activity...

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Detalles Bibliográficos
Autores principales: Lohan, Sandeep, Konshina, Anastasia G., Efremov, Roman G., Maslennikov, Innokentiy, Parang, Keykavous
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841524/
https://www.ncbi.nlm.nih.gov/pubmed/36574364
http://dx.doi.org/10.1021/acs.jmedchem.2c01708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841524/
https://www.ncbi.nlm.nih.gov/pubmed/36574364
http://dx.doi.org/10.1021/acs.jmedchem.2c01708

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