Cargando…

Structure-Based Rational Design of Small α-Helical Peptides with Broad-Spectrum Activity against Multidrug-Resistant Pathogens

[Image: see text] A series of small (7–12 mer) amphipathic cationic peptides were designed and synthesized to create short helical peptides with broad-range bactericidal activity and selectivity toward the bacterial cells. The analysis identified a lead 12-mer peptide 8b with broad-spectrum activity...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lohan, Sandeep, Konshina, Anastasia G., Efremov, Roman G., Maslennikov, Innokentiy, Parang, Keykavous
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841524/ https://www.ncbi.nlm.nih.gov/pubmed/36574364 http://dx.doi.org/10.1021/acs.jmedchem.2c01708

Ejemplares similares

Membrane-Active Cyclic Amphiphilic Peptides: Broad-Spectrum Antibacterial Activity Alone and in Combination with Antibiotics
por: Mohammed, Eman H. M., et al.
Publicado: (2022)

Antibacterial Activities of Amphiphilic Cyclic Cell-Penetrating Peptides against Multidrug-Resistant Pathogens
por: Oh, Donghoon, et al.
Publicado: (2014)

Amphiphilic Cell-Penetrating Peptides Containing Natural and Unnatural Amino Acids as Drug Delivery Agents
por: Salehi, David, et al.
Publicado: (2022)

Modified Linear Peptides Effectively Silence STAT-3 in Breast Cancer and Ovarian Cancer Cell Lines
por: Mandal, Dindyal, et al.
Publicado: (2023)

Cyclic Peptide-Gadolinium Nanocomplexes as siRNA Delivery Tools
por: Nasrolahi Shirazi, Amir, et al.
Publicado: (2021)

Cyclic Peptides with Antifungal Properties Derived from Bacteria, Fungi, Plants, and Synthetic Sources
por: Helmy, Naiera M., et al.
Publicado: (2023)

Cyclic Peptide-Gadolinium Nanoparticles for Enhanced Intracellular Delivery
por: Shirazi, Amir Nasrolahi, et al.
Publicado: (2020)

Rational design and application of responsive α-helical peptide hydrogels
por: Banwell, Eleanor F., et al.
Publicado: (2009)

Potent Broad-Spectrum Antibacterial Activity of Amphiphilic Peptides against Multidrug-Resistant Bacteria
por: Liu, Yuan, et al.
Publicado: (2020)

An engineered arginine-rich α-helical antimicrobial peptide exhibits broad-spectrum bactericidal activity against pathogenic bacteria and reduces bacterial infections in mice
por: Yang, Chin-Hao, et al.
Publicado: (2018)

Cyclic Peptide-Capped Gold Nanoparticles for Enhanced siRNA Delivery
por: Shirazi, Amir Nasrolahi, et al.
Publicado: (2014)

Comparative Molecular Transporter Efficiency of Cyclic Peptides Containing Tryptophan and Arginine Residues
por: Hanna, Samara E., et al.
Publicado: (2018)

Snake Cytotoxins Bind to Membranes via Interactions with Phosphatidylserine Head Groups of Lipids
por: Konshina, Anastasia G., et al.
Publicado: (2011)

The broad spectrum of pathogenic autoreactivity
por: Santambrogio, Laura, et al.
Publicado: (2022)

Design and Biological Evaluation of Colchicine-CD44-Targeted Peptide Conjugate in an In Vitro Model of Crystal Induced Inflammation
por: Zoghebi, Khalid A., et al.
Publicado: (2019)

Efficient Intracellular Delivery of Cell-Impermeable Cargo Molecules by Peptides Containing Tryptophan and Histidine
por: Shirazi, Amir Nasrolahi, et al.
Publicado: (2018)

Rationalizing the generation of broad spectrum antibiotics with the addition of a positive charge
por: Haloi, Nandan, et al.
Publicado: (2021)

Rational design of a helical peptide inhibitor targeting c-Myb–KIX interaction
por: Suetaka, Shunji, et al.
Publicado: (2022)

Evaluation of the Antimicrobial Peptide, RP557, for the Broad-Spectrum Treatment of Wound Pathogens and Biofilm
por: Woodburn, Kathryn Wynne, et al.
Publicado: (2019)

Rational engineering of a native hyperthermostable lactonase into a broad spectrum phosphotriesterase
por: Jacquet, Pauline, et al.
Publicado: (2017)

Cyclic Peptide–Selenium Nanoparticles as Drug Transporters
por: Nasrolahi Shirazi, Amir, et al.
Publicado: (2014)

Click-Free Synthesis of a Multivalent Tricyclic Peptide as a Molecular Transporter
por: Kumar, Sumit, et al.
Publicado: (2020)

A minimal length rigid helical peptide motif allows rational design of modular surfactants
por: Mondal, Sudipta, et al.
Publicado: (2017)

Enhanced Cellular Uptake of Short Polyarginine Peptides through Fatty Acylation and Cyclization
por: Oh, Donghoon, et al.
Publicado: (2014)

Tumor-targeted delivery of siRNA using fatty acyl-CGKRK peptide conjugates
por: Sharma, Meenakshi, et al.
Publicado: (2017)

Amphiphilic Cell-Penetrating Peptides Containing Arginine and Hydrophobic Residues as Protein Delivery Agents
por: Moreno, Jonathan, et al.
Publicado: (2023)

Difatty Acyl-Conjugated Linear and Cyclic Peptides for siRNA Delivery
por: Do, Hung, et al.
Publicado: (2017)

Rational Design of Berberine-Based FtsZ Inhibitors with Broad-Spectrum Antibacterial Activity
por: Sun, Ning, et al.
Publicado: (2014)

EDB-FN Targeted Peptide–Drug Conjugates for Use against Prostate Cancer
por: Park, Shang Eun, et al.
Publicado: (2019)

Combination of Amphiphilic Cyclic Peptide [R(4)W(4)] and Levofloxacin against Multidrug-Resistant Bacteria
por: Sajid, Muhammad Imran, et al.
Publicado: (2022)

Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C
por: Bauer, Lisa, et al.
Publicado: (2020)

Variability in the Spatial Structure of the Central Loop in Cobra Cytotoxins Revealed by X-ray Analysis and Molecular Modeling
por: Dubovskii, Peter V., et al.
Publicado: (2022)

Conversion of Broad-Spectrum Antimicrobial Peptides into Species-Specific Antimicrobials Capable of Precisely Targeting Pathogenic Bacteria
por: Xu, Lin, et al.
Publicado: (2020)

Amphiphilic Peptides for Efficient siRNA Delivery
por: Mozaffari, Saghar, et al.
Publicado: (2019)

Synthesis and Antiproliferative Activities of Conjugates of Paclitaxel and Camptothecin with a Cyclic Cell-Penetrating Peptide
por: El-Sayed, Naglaa Salem, et al.
Publicado: (2019)

Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors
por: Ramos-Molina, Bruno, et al.
Publicado: (2015)

Synthesis and antiviral activity of fatty acyl conjugates of remdesivir against severe acute respiratory syndrome coronavirus 2 and Ebola virus
por: El-Sayed, Naglaa Salem, et al.
Publicado: (2021)

Design, Synthesis, and Evaluation of Homochiral Peptides Containing Arginine and Histidine as Molecular Transporters
por: El-Sayed, Naglaa Salem, et al.
Publicado: (2018)

The Broad-Spectrum Antiviral Potential of the Amphibian Peptide AR-23
por: Chianese, Annalisa, et al.
Publicado: (2022)

HAZ, a novel peptide with broad-spectrum antibacterial activity
por: Alsaggar, Mohammad, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_utvd0srksvofdacis4lr8p7f0r