Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile-Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence

[Image: see text] Antivirulence agents targeting endospore-transmitted Clostridioides difficile infections are urgently needed. C. difficile-specific DNA adenine methyltransferase (CamA) is required for efficient sporulation and affects persistence in the colon. The active site of CamA is conserved...

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Detalles Bibliográficos
Autores principales: Zhou, Jujun, Horton, John R., Menna, Martina, Fiorentino, Francesco, Ren, Ren, Yu, Dan, Hajian, Taraneh, Vedadi, Masoud, Mazzoccanti, Giulia, Ciogli, Alessia, Weinhold, Elmar, Hüben, Michael, Blumenthal, Robert M., Zhang, Xing, Mai, Antonello, Rotili, Dante, Cheng, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841527/
https://www.ncbi.nlm.nih.gov/pubmed/36581322
http://dx.doi.org/10.1021/acs.jmedchem.2c01789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841527/
https://www.ncbi.nlm.nih.gov/pubmed/36581322
http://dx.doi.org/10.1021/acs.jmedchem.2c01789

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