Synthetic Strategies for Improving Solubility: Optimization of Novel Pyrazolo[1,5-a]pyrimidine CFTR Activator That Ameliorates Dry Eye Disease

[Image: see text] Dry eye disease (DED) is one of the most prevalent ocular diseases but has limited treatment options. Cystic fibrosis transmembrane conductance regulator (CFTR), a major chloride channel that stimulates fluid secretion in the ocular surface, may pave the way for new therapeutic str...

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Detalles Bibliográficos
Autores principales: Kim, Bo Yi, Oh, Changmok, Jeon, Dongkyu, Jun, Ikhyun, Lee, Ho K., Kim, Bo-Rahm, Park, Jinhong, Seo, Kyoung Yul, Kim, Kyeong-A, Lim, Dami, Lee, Seolhee, Lee, Jooyun, Yoon, Hongchul, Kim, Tae-im, Namkung, Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841530/
https://www.ncbi.nlm.nih.gov/pubmed/36573286
http://dx.doi.org/10.1021/acs.jmedchem.2c01382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841530/
https://www.ncbi.nlm.nih.gov/pubmed/36573286
http://dx.doi.org/10.1021/acs.jmedchem.2c01382

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