Exploring the Effect of Halogenation in a Series of Potent and Selective A(2B) Adenosine Receptor Antagonists

[Image: see text] The modulation of the A(2B) adenosine receptor is a promising strategy in cancer (immuno) therapy, with A(2B)AR antagonists emerging as immune checkpoint inhibitors. Herein, we report a systematic assessment of the impact of (di- and mono-)halogenation at positions 7 and/or 8 on bo...

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Detalles Bibliográficos
Autores principales: Prieto-Díaz, Rubén, González-Gómez, Manuel, Fojo-Carballo, Hugo, Azuaje, Jhonny, El Maatougui, Abdelaziz, Majellaro, Maria, Loza, María I., Brea, José, Fernández-Dueñas, Víctor, Paleo, M. Rita, Díaz-Holguín, Alejandro, Garcia-Pinel, Beatriz, Mallo-Abreu, Ana, Estévez, Juan C., Andújar-Arias, Antonio, García-Mera, Xerardo, Gomez-Tourino, Iria, Ciruela, Francisco, Salas, Cristian O., Gutiérrez-de-Terán, Hugo, Sotelo, Eddy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841532/
https://www.ncbi.nlm.nih.gov/pubmed/36517209
http://dx.doi.org/10.1021/acs.jmedchem.2c01768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841532/
https://www.ncbi.nlm.nih.gov/pubmed/36517209
http://dx.doi.org/10.1021/acs.jmedchem.2c01768

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