Identification of 2-Aminoacyl-1,3,4-thiadiazoles as Prostaglandin E(2) and Leukotriene Biosynthesis Inhibitors

[Image: see text] The application of a multi-step scientific workflow revealed an unprecedented class of PGE(2)/leukotriene biosynthesis inhibitors with in vivo activity. Specifically, starting from a combinatorial virtual library of ∼4.2 × 10(5) molecules, a small set of compounds was identified fo...

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Detalles Bibliográficos
Autores principales: Potenza, Marianna, Giordano, Assunta, Chini, Maria G., Saviano, Anella, Kretzer, Christian, Raucci, Federica, Russo, Marina, Lauro, Gianluigi, Terracciano, Stefania, Bruno, Ines, Iorizzi, Maria, Hofstetter, Robert K., Pace, Simona, Maione, Francesco, Werz, Oliver, Bifulco, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841589/
https://www.ncbi.nlm.nih.gov/pubmed/36655121
http://dx.doi.org/10.1021/acsmedchemlett.2c00343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841589/
https://www.ncbi.nlm.nih.gov/pubmed/36655121
http://dx.doi.org/10.1021/acsmedchemlett.2c00343

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