Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist

[Image: see text] The discovery of a novel 4-(4-aminopiperidinyl)-3,6-diarylquinoline series of potent SST2 agonists is described. This class of molecules exhibit excellent selectivity over SST1, SST3, SST4, and SST5 receptors. The compound 3-[4-(4-aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin...

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Detalles Bibliográficos
Autores principales: Zhao, Jian, Wang, Shimiao, Markison, Stacy, Kim, Sun Hee, Han, Sangdon, Chen, Mi, Kusnetzow, Ana Karin, Rico-Bautista, Elizabeth, Johns, Michael, Luo, Rosa, Struthers, R. Scott, Madan, Ajay, Zhu, Yunfei, Betz, Stephen F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841592/
https://www.ncbi.nlm.nih.gov/pubmed/36655128
http://dx.doi.org/10.1021/acsmedchemlett.2c00431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841592/
https://www.ncbi.nlm.nih.gov/pubmed/36655128
http://dx.doi.org/10.1021/acsmedchemlett.2c00431

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