Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors

[Image: see text] Among the most important influenza virus targets is the RNA-dependent RNA polymerase acidic N-terminal (PA(N)) endonuclease, which is a critical component of the viral replication machinery. To inhibit the activity of this metalloenzyme, small-molecule inhibitors employ metal-bindi...

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Detalles Bibliográficos
Autores principales: Stokes, Ryjul W., Kohlbrand, Alysia J., Seo, Hyeonglim, Sankaran, Banumathi, Karges, Johannes, Cohen, Seth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841593/
https://www.ncbi.nlm.nih.gov/pubmed/36655124
http://dx.doi.org/10.1021/acsmedchemlett.2c00434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841593/
https://www.ncbi.nlm.nih.gov/pubmed/36655124
http://dx.doi.org/10.1021/acsmedchemlett.2c00434

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