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Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors

[Image: see text] Among the most important influenza virus targets is the RNA-dependent RNA polymerase acidic N-terminal (PA(N)) endonuclease, which is a critical component of the viral replication machinery. To inhibit the activity of this metalloenzyme, small-molecule inhibitors employ metal-bindi...

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Detalles Bibliográficos
Autores principales:	Stokes, Ryjul W., Kohlbrand, Alysia J., Seo, Hyeonglim, Sankaran, Banumathi, Karges, Johannes, Cohen, Seth M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841593/ https://www.ncbi.nlm.nih.gov/pubmed/36655124 http://dx.doi.org/10.1021/acsmedchemlett.2c00434

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