Site-Selective Functionalization of Unactivated Allylic C–H Bonds via Direct Deprotonation with KTMP: Application to the Formal Total Synthesis of (+)-Artemisinin from Amorphadiene

[Image: see text] The site-selective functionalization of unactivated allylic C–H bonds via direct deprotonation using KTMP is described. The conversion of amorphadiene to artemisinic alcohol via a simple, highly regioselective deprotonation over 4 other possible allylic sites is shown with further...

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Detalles Bibliográficos
Autores principales: Clanton, Nicholas A., Wilson, Nicolas A., Ortiz, Eliezer, Blumberg, Shawn T., Frantz, Doug E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841608/
https://www.ncbi.nlm.nih.gov/pubmed/36592432
http://dx.doi.org/10.1021/acs.orglett.2c04145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841608/
https://www.ncbi.nlm.nih.gov/pubmed/36592432
http://dx.doi.org/10.1021/acs.orglett.2c04145

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