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Metabolic stress constrains microbial L-cysteine production in Escherichia coli by accelerating transposition through mobile genetic elements

BACKGROUND: L-cysteine is an essential chemical building block in the pharmaceutical-, cosmetic-, food and agricultural sector. Conventionally, L-cysteine production relies on the conversion of keratinous biomass mediated by hydrochloric acid. Today, fermentative production based on recombinant E. c...

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Detalles Bibliográficos
Autores principales: Heieck, Kevin, Arnold, Nathanael David, Brück, Thomas Bartholomäus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841684/
https://www.ncbi.nlm.nih.gov/pubmed/36642733
http://dx.doi.org/10.1186/s12934-023-02021-5