SARS-CoV-2 N protein mediates intercellular nucleic acid dispersion, a feature reduced in Omicron

The coronavirus nucleocapsid (N) protein is known to bind to nucleic acids and facilitate viral genome encapsulation. Here we report that the N protein can mediate RNA or DNA entering neighboring cells through ACE2-independent, receptor (STEAP2)-mediated endocytosis, and achieve gene expression. The...

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Detalles Bibliográficos
Autores principales: Wu, Jung-Lin, Kuan, I.-I., Guo, Jing-You, Hsu, Wei-Chia, Tang, Wei-Chun, Chan, Hsin-Ju, Chen, Yu-Ju, Chen, Bi-Chang, Wu, Han-Chung, Liao, James C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841735/
https://www.ncbi.nlm.nih.gov/pubmed/36687314
http://dx.doi.org/10.1016/j.isci.2023.105995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841735/
https://www.ncbi.nlm.nih.gov/pubmed/36687314
http://dx.doi.org/10.1016/j.isci.2023.105995

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