Valproate-coenzyme A conjugate blocks opening of receptor binding domains in the spike trimer of SARS-CoV-2 through an allosteric mechanism

The receptor-binding domains (RBDs) of the SARS-CoV-2 spike trimer exhibit "up" and "down" conformations often targeted by neutralizing antibodies. Only in the “up” configuration can RBDs bind to the ACE2 receptor of the host cell and initiate the process of viral multiplication....

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Detalles Bibliográficos
Autores principales: Maschietto, Federica, Qiu, Tianyin, Wang, Jimin, Shi, Yuanjun, Allen, Brandon, Lisi, George P., Lolis, Elias, Batista, Victor S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841741/
https://www.ncbi.nlm.nih.gov/pubmed/36688026
http://dx.doi.org/10.1016/j.csbj.2023.01.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841741/
https://www.ncbi.nlm.nih.gov/pubmed/36688026
http://dx.doi.org/10.1016/j.csbj.2023.01.014

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