Cargando…
Valproate-coenzyme A conjugate blocks opening of receptor binding domains in the spike trimer of SARS-CoV-2 through an allosteric mechanism
The receptor-binding domains (RBDs) of the SARS-CoV-2 spike trimer exhibit "up" and "down" conformations often targeted by neutralizing antibodies. Only in the “up” configuration can RBDs bind to the ACE2 receptor of the host cell and initiate the process of viral multiplication....
Autores principales: | Maschietto, Federica, Qiu, Tianyin, Wang, Jimin, Shi, Yuanjun, Allen, Brandon, Lisi, George P., Lolis, Elias, Batista, Victor S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research Network of Computational and Structural Biotechnology
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841741/ https://www.ncbi.nlm.nih.gov/pubmed/36688026 http://dx.doi.org/10.1016/j.csbj.2023.01.014 |
Ejemplares similares
-
Computational insights into the membrane fusion mechanism of SARS-CoV-2 at the cellular level
por: Wang, Jimin, et al.
Publicado: (2021) -
Mapping N- to C-terminal allosteric coupling through disruption of a putative CD74 activation site in D-dopachrome tautomerase
por: Chen, Emily, et al.
Publicado: (2023) -
How to correct relative voxel scale factors for calculations of vector-difference Fourier maps in cryo-EM
por: Wang, Jimin, et al.
Publicado: (2022) -
A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase
por: Chen, Emily, et al.
Publicado: (2021) -
A Cysteine Variant at an Allosteric Site Alters MIF Dynamics and Biological Function in Homo- and Heterotrimeric Assemblies
por: Skeens, Erin, et al.
Publicado: (2022)