Sulfonamide Prodrugs with a Two-Stage Release Mechanism for the Efficient Delivery of the TLR4 Antagonist TAK-242

[Image: see text] We previously demonstrated that the potent TLR4 inhibitor TAK-242 could be covalently conjugated to pancreatic islets using a linker that afforded an effective sustained delivery of the active drug after transplant. This drug-eluting tissue achieved local inhibition of TLR4-linked...

Descripción completa

Detalles Bibliográficos
Autores principales: Kostyo, Jessica H., Lallande, Avery T., Sells, Chloë A., Shuda, Mina R., Kane, Robert R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841982/
https://www.ncbi.nlm.nih.gov/pubmed/36660224
http://dx.doi.org/10.1021/acsmedchemlett.2c00492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841982/
https://www.ncbi.nlm.nih.gov/pubmed/36660224
http://dx.doi.org/10.1021/acsmedchemlett.2c00492

Ejemplares similares