PCSK9-D374Y Suppresses Hepatocyte Migration through Downregulating Free Cholesterol Efflux Rate and Activity of Extracellular Signal-Regulated Kinase

Proprotein convertase subtilisin/kexin type 9 can mediate the intracellular lysosomal degradation of the low-density lipoprotein receptor protein in hepatocytes and decrease the liver's ability to scavenge low-density lipoprotein cholesterol from circulation, resulting in high levels of cholest...

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Detalles Bibliográficos
Autores principales: Huang, Lei, Cheng, Ying, Mu, Yulian, Li, Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842426/
https://www.ncbi.nlm.nih.gov/pubmed/36655117
http://dx.doi.org/10.1155/2023/6985808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842426/
https://www.ncbi.nlm.nih.gov/pubmed/36655117
http://dx.doi.org/10.1155/2023/6985808

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