Identification of a short ACE2-derived stapled peptide targeting the SARS-CoV-2 spike protein

The design and synthesis of a series of peptide derivatives based on a short ACE2 α-helix 1 epitope and subsequent [i - i+4] stapling of the secondary structure resulted in the identification of a 9-mer peptide capable to compete with recombinant ACE2 towards Spike RBD in the micromolar range. Speci...

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Detalles Bibliográficos
Autores principales: Calugi, Lorenzo, Sautariello, Giulia, Lenci, Elena, Mattei, Mauro Leucio, Coppa, Crescenzo, Cini, Nicoletta, Contini, Alessandro, Trabocchi, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842534/
https://www.ncbi.nlm.nih.gov/pubmed/36682293
http://dx.doi.org/10.1016/j.ejmech.2023.115118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842534/
https://www.ncbi.nlm.nih.gov/pubmed/36682293
http://dx.doi.org/10.1016/j.ejmech.2023.115118

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