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Using mechanism similarity to understand enzyme evolution

Enzyme reactions take place in the active site through a series of catalytic steps, which are collectively termed the enzyme mechanism. The catalytic step is thereby the individual unit to consider for the purposes of building new enzyme mechanisms — i.e. through the mix and match of individual cata...

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Detalles Bibliográficos
Autores principales: Ribeiro, António J. M., Riziotis, Ioannis G., Tyzack, Jonathan D., Borkakoti, Neera, Thornton, Janet M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842563/
https://www.ncbi.nlm.nih.gov/pubmed/36659981
http://dx.doi.org/10.1007/s12551-022-01022-9