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mGluR5 is transiently confined in perisynaptic nanodomains to shape synaptic function

The unique perisynaptic distribution of postsynaptic metabotropic glutamate receptors (mGluRs) at excitatory synapses is predicted to directly shape synaptic function, but mechanistic insight into how this distribution is regulated and impacts synaptic signaling is lacking. We used live-cell and sup...

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Detalles Bibliográficos
Autores principales: Scheefhals, Nicky, Westra, Manon, MacGillavry, Harold D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842668/
https://www.ncbi.nlm.nih.gov/pubmed/36646691
http://dx.doi.org/10.1038/s41467-022-35680-w