Single and multiplexed gene repression in solventogenic Clostridium via Cas12a-based CRISPR interference

The Gram-positive, spore-forming, obligate anaerobic firmicute species that make up the Clostridium genus have broad feedstock consumption capabilities and produce value-added metabolic products, but genetic manipulation is difficult, limiting their broad appeal. CRISPR-Cas systems have recently bee...

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Detalles Bibliográficos
Autores principales: Joseph, Rochelle Carla, Sandoval, Nicholas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842803/
https://www.ncbi.nlm.nih.gov/pubmed/36687471
http://dx.doi.org/10.1016/j.synbio.2022.12.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842803/
https://www.ncbi.nlm.nih.gov/pubmed/36687471
http://dx.doi.org/10.1016/j.synbio.2022.12.005

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