The kynurenine pathway implicated in patient delirium: possible indications for indoleamine 2,3 dioxygenase inhibitors

Tryptophan (Trp) metabolism plays a central role in sleep, mood, and immune system regulation. The kynurenine pathway (KP), which is regulated by the enzymes tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3 dioxygenase (IDO), which catalyze the conversion of Trp to kynurenine (Kyn), facilitates...

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Detalles Bibliográficos
Autores principales: Heimberger, Amy B., Lukas, Rimas V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843043/
https://www.ncbi.nlm.nih.gov/pubmed/36647830
http://dx.doi.org/10.1172/JCI164577

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843043/
https://www.ncbi.nlm.nih.gov/pubmed/36647830
http://dx.doi.org/10.1172/JCI164577

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