Trained immunity is induced in humans after immunization with an adenoviral vector COVID-19 vaccine

BACKGROUND: Heterologous effects of vaccines are mediated by “trained immunity,” whereby myeloid cells are metabolically and epigenetically reprogrammed, resulting in heightened responses to subsequent insults. Adenovirus vaccine vector has been reported to induce trained immunity in mice. Therefore...

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Detalles Bibliográficos
Autores principales: Murphy, Dearbhla M., Cox, Donal J., Connolly, Sarah A., Breen, Eamon P., Brugman, Aenea A.I., Phelan, James J., Keane, Joseph, Basdeo, Sharee A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843058/
https://www.ncbi.nlm.nih.gov/pubmed/36282571
http://dx.doi.org/10.1172/JCI162581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843058/
https://www.ncbi.nlm.nih.gov/pubmed/36282571
http://dx.doi.org/10.1172/JCI162581

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