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Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients

BACKGROUND: The kynurenine pathway (KP) has been identified as a potential mediator linking acute illness to cognitive dysfunction by generating neuroactive metabolites in response to inflammation. Delirium (acute confusion) is a common complication of acute illness and is associated with increased...

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Detalles Bibliográficos
Autores principales: Watne, Leiv Otto, Pollmann, Christian Thomas, Neerland, Bjørn Erik, Quist-Paulsen, Else, Halaas, Nathalie Bodd, Idland, Ane-Victoria, Hassel, Bjørnar, Henjum, Kristi, Knapskog, Anne-Brita, Frihagen, Frede, Raeder, Johan, Godø, Aasmund, Ueland, Per Magne, McCann, Adrian, Figved, Wender, Selbæk, Geir, Zetterberg, Henrik, Fang, Evandro F., Myrstad, Marius, Giil, Lasse M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843060/
https://www.ncbi.nlm.nih.gov/pubmed/36409557
http://dx.doi.org/10.1172/JCI163472