mTOR regulates T cell exhaustion and PD-1–targeted immunotherapy response during chronic viral infection

T cell exhaustion is a state of T cell dysfunction associated with expression of programmed death 1 (PD-1). Exhausted CD8(+) T cells are maintained by self-renewing stem-like T cells that provide differentiated TIM3(+) cells, a part of which possesses effector-like properties. PD-1–targeted therapie...

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Detalles Bibliográficos
Autores principales: Ando, Satomi, Perkins, Charles M., Sajiki, Yamato, Chastain, Chase, Valanparambil, Rajesh M., Wieland, Andreas, Hudson, William H., Hashimoto, Masao, Ramalingam, Suresh S., Freeman, Gordon J., Ahmed, Rafi, Araki, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843061/
https://www.ncbi.nlm.nih.gov/pubmed/36378537
http://dx.doi.org/10.1172/JCI160025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843061/
https://www.ncbi.nlm.nih.gov/pubmed/36378537
http://dx.doi.org/10.1172/JCI160025

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