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mTOR regulates T cell exhaustion and PD-1–targeted immunotherapy response during chronic viral infection
T cell exhaustion is a state of T cell dysfunction associated with expression of programmed death 1 (PD-1). Exhausted CD8(+) T cells are maintained by self-renewing stem-like T cells that provide differentiated TIM3(+) cells, a part of which possesses effector-like properties. PD-1–targeted therapie...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Clinical Investigation
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843061/ https://www.ncbi.nlm.nih.gov/pubmed/36378537 http://dx.doi.org/10.1172/JCI160025 |