Riluzole and novel naphthalenyl substituted aminothiazole derivatives prevent acute neural excitotoxic injury in a rat model of temporal lobe epilepsy

Epileptogenic seizures, or status epilepticus (SE), leads to excitotoxic injury in hippocampal and limbic neurons in the kainic acid (KA) animal model of temporal lobe epilepsy (TLE). Here, we have further characterized neural activity regulated methylaminoisobutryic acid (MeAIB)/glutamine transport...

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Detalles Bibliográficos
Autores principales: Kyllo, Thomas, Singh, Vikrant, Shim, Heesung, Latika, Singh, Nguyen, Hai M., Chen, Yi-Je, Terry, Ellen, Wulff, Heike, Erickson, Jeffrey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843824/
https://www.ncbi.nlm.nih.gov/pubmed/36436594
http://dx.doi.org/10.1016/j.neuropharm.2022.109349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843824/
https://www.ncbi.nlm.nih.gov/pubmed/36436594
http://dx.doi.org/10.1016/j.neuropharm.2022.109349

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