Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation

BACKGROUND: CRISPR-based toolkits have dramatically increased the ease of genome and epigenome editing. SpCas9 is the most widely used nuclease. However, the difficulty of delivering SpCas9 and inability to modulate its expression in vivo hinder its widespread adoption in large animals. RESULTS: Her...

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Detalles Bibliográficos
Autores principales: Jin, Qin, Liu, Xiaoyi, Zhuang, Zhenpeng, Huang, Jiayuan, Gou, Shixue, Shi, Hui, Zhao, Yu, Ouyang, Zhen, Liu, Zhaoming, Li, Lei, Mao, Junjie, Ge, Weikai, Chen, Fangbing, Yu, Manya, Guan, Yezhi, Ye, Yinghua, Tang, Chengcheng, Huang, Ren, Wang, Kepin, Lai, Liangxue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843877/
https://www.ncbi.nlm.nih.gov/pubmed/36650523
http://dx.doi.org/10.1186/s13059-023-02851-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843877/
https://www.ncbi.nlm.nih.gov/pubmed/36650523
http://dx.doi.org/10.1186/s13059-023-02851-x

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