Intestinal epithelium penetration of liraglutide via cholic acid pre-complexation and zein/rhamnolipids nanocomposite delivery

BACKGROUND: Oral administration offered a painless way and improved compliance for diabetics. However, the emerging GLP-1 analog peptide drugs for diabetes primarily rely on the injection route, and the development of oral dosage forms was hampered by the low oral bioavailability due to the structur...

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Detalles Bibliográficos
Autores principales: Bao, Xiaoyan, Qian, Kang, Xu, Mengjiao, Chen, Yi, Wang, Hao, Pan, Ting, Wang, Zhengyi, Yao, Ping, Lin, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843898/
https://www.ncbi.nlm.nih.gov/pubmed/36647125
http://dx.doi.org/10.1186/s12951-022-01743-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843898/
https://www.ncbi.nlm.nih.gov/pubmed/36647125
http://dx.doi.org/10.1186/s12951-022-01743-9

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