A pH-dependent anti-CD47 antibody that selectively targets solid tumors and improves therapeutic efficacy and safety

BACKGROUND: The antiphagocytic molecule CD47 is overexpressed in a wide variety of cancer cells, and antibodies targeting CD47 for cancer therapies are currently under intensive investigation. However, owing to the ubiquitous expression of CD47 on healthy cells, anti-CD47 therapies often achieve onl...

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Detalles Bibliográficos
Autores principales: Li, Yulu, Liu, Juan, Chen, Wei, Wang, Wei, Yang, Fang, Liu, Ximing, Sheng, Yao, Du, Kaixin, He, Miaomiao, Lyu, Xueyuan, Li, Huiyu, Zhao, Linlin, Wei, Zhizhong, Wang, Fengchao, Zheng, Sanduo, Sui, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844003/
https://www.ncbi.nlm.nih.gov/pubmed/36650558
http://dx.doi.org/10.1186/s13045-023-01399-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844003/
https://www.ncbi.nlm.nih.gov/pubmed/36650558
http://dx.doi.org/10.1186/s13045-023-01399-4

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