Tris(4-azidophenyl)methanol – a novel and multifunctional thiol protecting group

The novel tris(4-azidophenyl)methanol, a multifunctionalisable aryl azide, is reported. The aryl azide can be used as a protecting group for thiols in peptoid synthesis and can be cleaved under mild reaction conditions via a Staudinger reduction. Moreover, the easily accessible aryl azide can be fun...

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Autores principales: Qiu, Xujun, Brückel, Julian, Zippel, Christoph, Nieger, Martin, Biedermann, Frank, Bräse, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844210/
https://www.ncbi.nlm.nih.gov/pubmed/36741178
http://dx.doi.org/10.1039/d2ra05997e
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author Qiu, Xujun
Brückel, Julian
Zippel, Christoph
Nieger, Martin
Biedermann, Frank
Bräse, Stefan
author_facet Qiu, Xujun
Brückel, Julian
Zippel, Christoph
Nieger, Martin
Biedermann, Frank
Bräse, Stefan
author_sort Qiu, Xujun
collection PubMed
description The novel tris(4-azidophenyl)methanol, a multifunctionalisable aryl azide, is reported. The aryl azide can be used as a protecting group for thiols in peptoid synthesis and can be cleaved under mild reaction conditions via a Staudinger reduction. Moreover, the easily accessible aryl azide can be functionalised via copper-catalysed cycloaddition reactions, providing additional opportunities for materials chemistry applications.
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spelling pubmed-98442102023-02-03 Tris(4-azidophenyl)methanol – a novel and multifunctional thiol protecting group Qiu, Xujun Brückel, Julian Zippel, Christoph Nieger, Martin Biedermann, Frank Bräse, Stefan RSC Adv Chemistry The novel tris(4-azidophenyl)methanol, a multifunctionalisable aryl azide, is reported. The aryl azide can be used as a protecting group for thiols in peptoid synthesis and can be cleaved under mild reaction conditions via a Staudinger reduction. Moreover, the easily accessible aryl azide can be functionalised via copper-catalysed cycloaddition reactions, providing additional opportunities for materials chemistry applications. The Royal Society of Chemistry 2023-01-17 /pmc/articles/PMC9844210/ /pubmed/36741178 http://dx.doi.org/10.1039/d2ra05997e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Qiu, Xujun
Brückel, Julian
Zippel, Christoph
Nieger, Martin
Biedermann, Frank
Bräse, Stefan
Tris(4-azidophenyl)methanol – a novel and multifunctional thiol protecting group
title Tris(4-azidophenyl)methanol – a novel and multifunctional thiol protecting group
title_full Tris(4-azidophenyl)methanol – a novel and multifunctional thiol protecting group
title_fullStr Tris(4-azidophenyl)methanol – a novel and multifunctional thiol protecting group
title_full_unstemmed Tris(4-azidophenyl)methanol – a novel and multifunctional thiol protecting group
title_short Tris(4-azidophenyl)methanol – a novel and multifunctional thiol protecting group
title_sort tris(4-azidophenyl)methanol – a novel and multifunctional thiol protecting group
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844210/
https://www.ncbi.nlm.nih.gov/pubmed/36741178
http://dx.doi.org/10.1039/d2ra05997e
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