Cargando…

Development and transdifferentiation into inner hair cells require Tbx2

Atoh1 is essential for the development of both outer hair cells (OHCs) and inner hair cells (IHCs) in the mammalian cochlea. Whereas Ikzf2 is necessary for OHC development, the key gene required for IHC development remains unknown. We found that deletion of Tbx2 in neonatal IHCs led to their transdi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bi, Zhenghong, Li, Xiang, Ren, Minhui, Gu, Yunpeng, Zhu, Tong, Li, Shuting, Wang, Guangqin, Sun, Suhong, Sun, Yuwei, Liu, Zhiyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844247/ https://www.ncbi.nlm.nih.gov/pubmed/36687561 http://dx.doi.org/10.1093/nsr/nwac156

Ejemplares similares

Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells
por: Sun, Suhong, et al.
Publicado: (2021)

TBX2 specifies and maintains inner hair and supporting cell fate in the Organ of Corti
por: Kaiser, Marina, et al.
Publicado: (2022)

Tbx18 Orchestrates Cytostructural Transdifferentiation of Cardiomyocytes to Pacemaker Cells by Recruiting the Epithelial–Mesenchymal Transition Program
por: Foster, D. Brian, et al.
Publicado: (2022)

Comprehensive transcriptome analysis of cochlear spiral ganglion neurons at multiple ages
por: Li, Chao, et al.
Publicado: (2020)

Editorial: The mechanism on development and regeneration of inner ear hair cells
por: Sun, Haojie, et al.
Publicado: (2022)

Three distinct Atoh1 enhancers cooperate for sound receptor hair cell development
por: Luo, Zhengnan, et al.
Publicado: (2022)

Tbx4 and Tbx5 acting in connective tissue are required for limb muscle and tendon patterning
por: Hasson, Peleg, et al.
Publicado: (2010)

TBX2 and TBX3: The special value for anticancer drug targets
por: Lu, Juan, et al.
Publicado: (2010)

Striatin Is Required for Hearing and Affects Inner Hair Cells and Ribbon Synapses
por: Nadar-Ponniah, Prathamesh T., et al.
Publicado: (2020)

Identification of TBX2 and TBX3 variants in patients with conotruncal heart defects by target sequencing
por: Xie, Huilin, et al.
Publicado: (2018)

LKB1 Is Required for the Development and Maintenance of Stereocilia in Inner Ear Hair Cells in Mice
por: Men, Yuqin, et al.
Publicado: (2015)

Tbx15 is required for adipocyte browning induced by adrenergic signaling pathway
por: Sun, Wei, et al.
Publicado: (2019)

HCN Channels Are Not Required for Mechanotransduction in Sensory Hair Cells of the Mouse Inner Ear
por: Horwitz, Geoffrey C., et al.
Publicado: (2010)

Synaptic activity is not required for establishing heterogeneity of inner hair cell ribbon synapses
por: Karagulyan, Nare, et al.
Publicado: (2023)

Transdifferentiation of Human Hair Follicle Mesenchymal Stem Cells into Red Blood Cells by OCT4
por: Liu, Zhijing, et al.
Publicado: (2015)

Tbx1 regulates Vegfr3 and is required for lymphatic vessel development
por: Chen, Li, et al.
Publicado: (2010)

A critical period of prehearing spontaneous Ca(2+) spiking is required for hair‐bundle maintenance in inner hair cells
por: Carlton, Adam J, et al.
Publicado: (2023)

A divergent Tbx6-related gene and Tbx6 are both required for neural crest and intermediate mesoderm development in Xenopus
por: Callery, Elizabeth M., et al.
Publicado: (2010)

Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea
por: Bardhan, Tanaya, et al.
Publicado: (2019)

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation
por: Corns, Laura F., et al.
Publicado: (2018)

Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses
por: Lee, John, et al.
Publicado: (2021)

Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development
por: Greulich, Franziska, et al.
Publicado: (2016)

ETV2 mediates endothelial transdifferentiation of glioblastoma
por: Zhao, Chengjian, et al.
Publicado: (2018)

Fss/Tbx6 is required for central dermomyotome cell fate in zebrafish
por: Windner, Stefanie Elisabeth, et al.
Publicado: (2012)

RIM-Binding Proteins Are Required for Normal Sound-Encoding at Afferent Inner Hair Cell Synapses
por: Krinner, Stefanie, et al.
Publicado: (2021)

Is transdifferentiation in trouble?
por: Wells, William A.
Publicado: (2002)

FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway
por: He, Zu-Hong, et al.
Publicado: (2021)

Cardiogenol C can induce Mouse Hair Bulge Progenitor Cells to Transdifferentiate into Cardiomyocyte-like Cells
por: Yau, Winifred WY, et al.
Publicado: (2011)

Tbx18 targets dermal condensates for labeling, isolation and gene ablation during embryonic hair follicle formation
por: Grisanti, Laura, et al.
Publicado: (2012)

Chaotic Dynamics of Inner Ear Hair Cells
por: Faber, Justin, et al.
Publicado: (2018)

Apoptosis in inner ear sensory hair cells
por: Morrill, Seth, et al.
Publicado: (2017)

Multiple Roles and Interactions of Tbx4 and Tbx5 in Development of the Respiratory System
por: Arora, Ripla, et al.
Publicado: (2012)

Corneal Limbal Microenvironment Can Induce Transdifferentiation of Hair Follicle Stem Cells into Corneal Epithelial-like Cells
por: Blazejewska, Ewa Anna, et al.
Publicado: (2009)

Lgr5+ Cells Regenerate Hair Cells via Proliferation and Direct Transdifferentiation in Damaged Neonatal Mouse Utricle
por: Wang, Tian, et al.
Publicado: (2015)

Identification, Functional Study, and Promoter Analysis of HbMFT1, a Homolog of MFT from Rubber Tree (Hevea brasiliensis)
por: Bi, Zhenghong, et al.
Publicado: (2016)

Tbx2 and Tbx3 Regulate the Dynamics of Cell Proliferation during Heart Remodeling
por: Ribeiro, Inês, et al.
Publicado: (2007)

Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation
por: Singh, Reena, et al.
Publicado: (2011)

Expression of TBX3 in Hepatocellular Carcinoma and Its Clinical Implication
por: Li, Zhian, et al.
Publicado: (2018)

Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1
por: Wiwatpanit, Teerawat, et al.
Publicado: (2018)

Otoferlin Is Required for Proper Synapse Maturation and for Maintenance of Inner and Outer Hair Cells in Mouse Models for DFNB9
por: Stalmann, Ursula, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_g7rlv7urn4q4n6ja5qtltslkam