Promoter sequence and architecture determine expression variability and confer robustness to genetic variants

Genetic and environmental exposures cause variability in gene expression. Although most genes are affected in a population, their effect sizes vary greatly, indicating the existence of regulatory mechanisms that could amplify or attenuate expression variability. Here, we investigate the relationship...

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Detalles Bibliográficos
Autores principales: Einarsson, Hjörleifur, Salvatore, Marco, Vaagensø, Christian, Alcaraz, Nicolas, Bornholdt, Jette, Rennie, Sarah, Andersson, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844987/
https://www.ncbi.nlm.nih.gov/pubmed/36377861
http://dx.doi.org/10.7554/eLife.80943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844987/
https://www.ncbi.nlm.nih.gov/pubmed/36377861
http://dx.doi.org/10.7554/eLife.80943

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