Enrichment of hepatic glycogen and plasma glucose from H₂(18)O informs gluconeogenic and indirect pathway fluxes in naturally feeding mice

Deuterated water ((2)H(2)O) is a widely used tracer of carbohydrate biosynthesis in both preclinical and clinical settings, but the significant kinetic isotope effects (KIE) of (2)H can distort metabolic information and mediate toxicity. (18)O‐water (H(2) (18)O) has no significant KIE and is incorpo...

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Detalles Bibliográficos
Autores principales: Coelho, Margarida, Mahar, Rohit, Belew, Getachew D., Torres, Alejandra, Barosa, Cristina, Cabral, Fernando, Viegas, Ivan, Gastaldelli, Amalia, Mendes, Vera M., Manadas, Bruno, Jones, John G., Merritt, Matthew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845176/
https://www.ncbi.nlm.nih.gov/pubmed/36151589
http://dx.doi.org/10.1002/nbm.4837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845176/
https://www.ncbi.nlm.nih.gov/pubmed/36151589
http://dx.doi.org/10.1002/nbm.4837

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