Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis

Lipid nanoparticle-mediated RNA delivery holds great potential to treat various liver diseases. However, targeted delivery of RNA therapeutics to activated liver-resident fibroblasts for liver fibrosis treatment remains challenging. Here, we develop a combinatorial library of anisamide ligand-tether...

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Detalles Bibliográficos
Autores principales: Han, Xuexiang, Gong, Ningqiang, Xue, Lulu, Billingsley, Margaret M., El-Mayta, Rakan, Shepherd, Sarah J., Alameh, Mohamad-Gabriel, Weissman, Drew, Mitchell, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845313/
https://www.ncbi.nlm.nih.gov/pubmed/36650129
http://dx.doi.org/10.1038/s41467-022-35637-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845313/
https://www.ncbi.nlm.nih.gov/pubmed/36650129
http://dx.doi.org/10.1038/s41467-022-35637-z

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