Enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65

Prime editing is a versatile gene editing tool that enables precise sequence changes of all types in the genome, but its application is rather limited by the editing efficiency. Here, we first apply the Suntag system to recruit the transcription factor P65 and enhance the desired editing outcomes in...

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Detalles Bibliográficos
Autores principales: Chen, Ronghao, Cao, Yu, Liu, Yajing, Zhao, Dongdong, Li, Ju, Cheng, Zhihui, Bi, Changhao, Zhang, Xueli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845348/
https://www.ncbi.nlm.nih.gov/pubmed/36650182
http://dx.doi.org/10.1038/s41467-023-35919-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845348/
https://www.ncbi.nlm.nih.gov/pubmed/36650182
http://dx.doi.org/10.1038/s41467-023-35919-0

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