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Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington’s disease
Striatal projection neurons (SPNs), which progressively degenerate in human patients with Huntington’s disease (HD), are classified along two axes: the canonical direct-indirect pathway division and the striosome-matrix compartmentation. It is well established that the indirect-pathway SPNs are susc...
Autores principales: | Matsushima, Ayano, Pineda, Sergio Sebastian, Crittenden, Jill R., Lee, Hyeseung, Galani, Kyriakitsa, Mantero, Julio, Tombaugh, Geoffrey, Kellis, Manolis, Heiman, Myriam, Graybiel, Ann M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845362/ https://www.ncbi.nlm.nih.gov/pubmed/36650127 http://dx.doi.org/10.1038/s41467-022-35752-x |
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