ATM inhibitor KU60019 synergistically sensitizes lung cancer cells to topoisomerase II poisons by multiple mechanisms

Type II topoisomerases (TOP2) poisons represent one class of the most successful and widely prescribed chemotherapeutics, which is frontline therapy for a myriad of systemic cancers and solid tumors, including lymphomas, leukemias, and lung cancer. Despite this, treatment with this class of drugs in...

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Detalles Bibliográficos
Autores principales: Shu, Jianfeng, Wang, Xiaofang, Yang, Xuejie, Zhao, Guofang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845372/
https://www.ncbi.nlm.nih.gov/pubmed/36650267
http://dx.doi.org/10.1038/s41598-023-28185-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845372/
https://www.ncbi.nlm.nih.gov/pubmed/36650267
http://dx.doi.org/10.1038/s41598-023-28185-z

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