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Vasoactive intestinal peptide blockade suppresses tumor growth by regulating macrophage polarization and function in CT26 tumor-bearing mice
Macrophages are a major population of immune cells in solid cancers, especially colorectal cancers. Tumor-associated macrophages (TAMs) are commonly divided into M1-like (tumor suppression) and M2-like (tumor promotion) phenotypes. Vasoactive intestinal peptide (VIP) is an immunoregulatory neuropept...
Autores principales: | Kittikulsuth, Wararat, Nakano, Daisuke, Kitada, Kento, Uyama, Toru, Ueda, Natsuo, Asano, Eisuke, Okano, Keiichi, Matsuda, Yoko, Nishiyama, Akira |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845384/ https://www.ncbi.nlm.nih.gov/pubmed/36650220 http://dx.doi.org/10.1038/s41598-023-28073-6 |
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