Suppression of YAP safeguards human naïve pluripotency

Propagation of human naïve pluripotent stem cells (nPSCs) relies on the inhibition of MEK/ERK signalling. However, MEK/ERK inhibition also promotes differentiation into trophectoderm (TE). Therefore, robust self-renewal requires suppression of TE fate. Tankyrase inhibition using XAV939 has been show...

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Detalles Bibliográficos
Autores principales: Dattani, Anish, Huang, Tao, Liddle, Corin, Smith, Austin, Guo, Ge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Stem Cells and Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845734/
https://www.ncbi.nlm.nih.gov/pubmed/36398796
http://dx.doi.org/10.1242/dev.200988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845734/
https://www.ncbi.nlm.nih.gov/pubmed/36398796
http://dx.doi.org/10.1242/dev.200988

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