Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development

Spatiotemporal regulation of the mechanistic target of rapamycin (mTOR) pathway is pivotal for establishment of brain architecture. Dysregulation of mTOR signaling is associated with a variety of neurodevelopmental disorders. Here, we demonstrate that the UBE4B-KLHL22 E3 ubiquitin ligase cascade reg...

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Detalles Bibliográficos
Autores principales: Kong, Xiangxing, Shu, Xin, Wang, Jiachuan, Liu, Dandan, Ni, Yingchun, Zhao, Weiqi, Wang, Lebo, Gao, Zhihua, Chen, Jiadong, Yang, Bing, Guo, Xing, Wang, Zhiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845739/
https://www.ncbi.nlm.nih.gov/pubmed/36440598
http://dx.doi.org/10.1242/dev.201286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845739/
https://www.ncbi.nlm.nih.gov/pubmed/36440598
http://dx.doi.org/10.1242/dev.201286

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